Categories
Uncategorized

why and how ELISA testing can be/is being used for COVID-19 serological antibody testing

Covid-19diagnostictesting,antibodytesting,andtracing,areregardedaskey to reopening countries currently dealing with the coronavirus pandemic. Your assignment is to research current scientific literature and write a paper (about 10 pages,…

Covid-19diagnostictesting,antibodytesting,andtracing,areregardedaskey to reopening countries currently dealing with the coronavirus pandemic. Your assignment is to research current scientific literature and write a paper (about 10 pages, references included, double-spaced, 1-inch margins, 12 point font) dealing with why and how ELISA testing can be/is being used for COVID-19 serological antibody testing.
Considerations for your paper: Style of assay- ELISA vs.lateral flow immunoassay ELISA antibody testing vs. diagnostic antigen testing. Significance of isotype detection: IgM vs. IgG, and timing Antigen choice for the assay Distinction between presence of antigen-specific antibodies and immunity Specificity-The SARS-CoV-2 virus that causes Covid-19, as well as SARS,MERS, and the common cold, are all coronaviruses – how would an ELISA testdistinguish among exposure to them Test accuracy-sensitivity vs. specificity-Bayes Theorem as applies to test sensitivity and specificity -How might one arrive at a prior hypothesis?-Random vs. non-random sample testing in evaluating the assay -Effect of the frequency of a disease in the population You must properly reference your work:-References should primarily be from the scientific literature. -Given how recent this disease is you may use article preprints orpostings on medRxiv and bioRxiv.-Any other non-journal references should be from reputable sources,e.g., Stat.-Reputable mainstream news sources, e.g., New York Times articles, maybe helpful as a secondary source to lead you to a primary scientific source. Notewell:This is a scientific paper – do not include political or fringe points of view.

Leave a Reply

Your email address will not be published. Required fields are marked *